Study: Clinical Characteristics of Preterm Neonates with Agg
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Researchers aimed to identify the risk factors that may predispose preterm neonates to develop aggressive posterior retinopathy of prematurity (APROP).

This retrospective case control study included 16 infants with APROP in zone 1 or posterior zone 2. 34 gestational age and birth weight-matched controls with stage 2 or less ROP were included. Medical records on infant birth and postnatal characteristics were reviewed

Results:
--Patients who developed APROP had a significantly longer duration of caffeine therapy, were significantly more likely to be small for gestational age (SGA), and were more likely to have a positive blood culture than patients who developed less severe ROP.

--Patients with APROP who required retreatment had received inotropes for a longer duration of time, had received more plasma transfusions, were more likely to have IVH, and had a greater decrease in the serum hemoglobin during hospitalization.

Finally, APROP was linked to being SGA, getting caffeine for a longer period of time, and having culture-proven sepsis. APROP was linked to IVH, low serum hemoglobin, the need for additional plasma transfusions, and a longer duration of inotropes, all of which necessitated retreatment.

Source: https://www.dovepress.com/clinical-characteristics-of-preterm-neonates-with-aggressive-posterior-peer-reviewed-fulltext-article-OPTH
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