Study: Cyclosporine 0.09% Treatment is Efficacious in Dry Ey
A Study was conducted to determine the effect of topical cyclosporine 0.09% on ocular surface regularity and the predictive accuracy of preoperative corneal power measurements in patients undergoing cataract surgery.

75 patients who presented for cataract surgery evaluation with signs of dry eye disease were prescribed topical cyclosporine 0.09% for 28 days BID. Cataract surgery occurred 1 to 3 weeks after the second biometry visit. Refraction and corrected distance visual acuity measurements were performed 1-month post-surgery.

--64 patients completed the study. The absolute prediction error of 1-month spherical equivalent refractive outcome was 0.39 ± 0.30 D vs 0.33 ± 0.25 D before and after treatment, respectively.

--The proportion of eyes that achieved the target refraction was greater based on measurements after topical cyclosporine 0.09% than would have occurred using pre-treatment measurements.

Patients with dry eyes who were given topical cyclosporine 0.09 percent BID for 28 days prior to surgery had a statistically significant reduction in the prediction error of the spherical equivalent outcome of surgery. Other indicators of dry eye severity improved significantly following treatment.