Study Finds, Associations Between Subclass Profile of IgG Re
Gastrointestinal problems are often seen in children with cerebral palsy, although the etiology and underlying mechanisms are not fully understood. Researchers aimed to further characterize antibody response by examining its subclass distribution and target reactivity in the context of relevant patient symptom profile.

Study participants included children with cerebral palsy and celiac disease, as well as unaffected controls. Serum IgG antibody to gluten was investigated for subclass distribution, pattern of reactivity towards target proteins, and relationship with gastrointestinal symptoms and motor function.

--The anti-gluten IgG antibody response in the cerebral palsy cohort was constituted of all 4 subclasses.

--In comparison with celiac disease, however, IgG1, IgG2, and IgG3 subclasses were significantly lower, whereas the IgG4 response was significantly higher in cerebral palsy.

--Within the cohort of cerebral palsy patients, levels of anti-gluten IgG1, IgG3, and IgG4 were greater in those with gastrointestinal symptoms, and the IgG3 subclass antibody correlated inversely with gross motor function.

--The anti-gluten IgG antibodies targeted a broad range of gliadin and glutenin proteins.

Conclusively, study show that the distribution of anti-gluten IgG subclasses in cerebral palsy differs significantly from that in celiac disease. Furthermore, the link between IgG subclass and symptom profile suggests a link between immune response and disease pathogenesis, suggesting that impairments in gut immunological and barrier function may play a role in cerebral palsy.