Study Finds, Risk Factors for Ocular Involvement in Pediatri
A Study was conducted to identify risk factors for ocular graft-versus-host disease (oGVHD) in children with graft-versus-host disease (GVHD).

38 children diagnosed with GVHD who underwent an ophthalmological examination. Survival to onset of oGVHD after transplant was analyzed using Kaplan–Meier analyses with log-rank tests. A multivariable Cox proportional hazards model was run for time to oGVHD using univariate risk factors.

--Underlying illness was acute lymphoblastic leukemia in 19 and acute myeloid leukemia in 8.

--Nonocular GVHD organ involvement included skin, lungs, intestines, liver, and bone marrow.

--Fifteen children had oGVHD, of which 47% were asymptomatic. oGVHD was diagnosed 601 ± 878 days after GVHD.

--A significant association between risk of oGVHD and diagnosis of acute lymphoblastic leukemia or acute myeloid leukemia was not found.

--Organ involvement associated with oGVHD included skin and lungs.

--Survival curves were significantly influenced by GVHD organ involvement, but not underlying disease.

--The adjusted Cox regression model yielded an independent hazard ratio of 8.82 for the presence of concomitant GVHD involvement of skin, lungs, and another organ.

Conclusively, Children with multiorgan GVHD, including skin and lung disease, are more likely to develop oGVHD. Regular eye examinations are recommended in this population, given the high incidence of asymptomatic patients identified in this series.