Study, Foveal Muller Cell Cone acts as a Prognostic OCT Biom
A Study was conducted to investigate the effect of the foveal Muller cell cone structure on the anatomical and functional response to intravitreal bevacizumab (IVB) treatment in patients with diabetic macular edema (DME).

Retrospective spectral-domain OCT images of 93 treatment-naive eyes with center-involved cystic type DME were assessed to determine foveal Muller cell cone structure and predictive characteristics such as length of disorganization in the retinal inner layers (DRIL) and ellipsoid zone (EZ) disruption. OCT angiography was used to assess the extent and circularity of the foveal avascular zone (FAZ) of a superficial and deep capillary plexus (SCP and DCP) 1 month after IVB.

--Destruction of foveal Muller cell cone structure and a large FAZ in the DCP (mm2) correlated strongly with a poor anatomical response (CST more than 250 microm) at 1 month after 1st IVB (Exp(B) = 29.444 and Exp(B) = 12.419 respectively).

--A destroyed Muller cell cone structure and length of EZ disruption at baseline were associated with poor visual acuity at 1 month after the 1st IVB.

In conclusion, the structure of the foveal Muller cell cone correlates with the response to early anti-VEGF treatment.