Study: Long-term Outcomes after Postnatal Cytomegalovirus In
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Cytomegalovirus (CMV) is the most common viral infection seen in newborns. Although postnatally acquired CMV (pCMV) infection rarely results in serious manifestations in term infants, preterm infants can develop severe clinical illness. Few robust studies on long-term outcomes of pCMV infection have been performed, and those reported often present conflicting results. The objective was to assess the long-term outcomes for low birthweight (LBW) preterm infants after pCMV infection.

Case reports, observational, experimental and randomized controlled trials that examined pCMV in preterm or VLBW infants and long-term (more than 1 month) impact of pCMV were included.

Results:
--pCMV infection in preterm infants was associated with increased risk for pulmonary and neurologic complications and increases length of stay. There is less evidence to suggest that pCMV is associated with necrotizing enterocolitis, ophthalmologic, audiologic and anthropomorphic complications in preterm infants.

Finally, relative to their pCMV-negative equivalents, preterm infants with pCMV, particularly those with symptomatic infection, may have long-term pulmonary and neurodevelopmental morbidity. The importance of pCMV diagnosis and prevention in preterm infants in the neonatal intensive care unit is highlighted by these findings.

Source: https://journals.lww.com/pidj/Fulltext/2021/06000/Long_term_Outcomes_after_Postnatal_Cytomegalovirus.16.aspx
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