Study: Penetrating Keratoplasty in Infants With Peters Anoma
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A Study was conducted that determined the prevalence of survival of corneal grafts and visual outcomes of primary penetrating keratoplasty (PK) in infants with Peters anomaly (PA).

The researchers looked at 29 PA patients (37 eyes) who had PK before the age of one year. 2 weeks after the sutures were removed, optical correction for both eyes and amblyopia occlusion therapy for a unilateral opacity were performed. Both children's visual acuity was checked after surgery using Teller Acuity Cards. The log-rank test and the Kaplan–Meier approach were used to determine survival probabilities. Visual outcomes and prognosis variables were investigated using the X2 test.

Results:
--The mean age of 29 infants undergoing primary PK was 5.7 ± 2.3 months. The mean follow-up duration was 18.0 ± 3.0 months.

--27 of 37 grafts retained full clarity at final follow-up. Visual acuity above ambulatory was achieved in 67.6% and more than 20/260 was achieved in 48.6% of cases.

--Of all surgical indications, vascularized PA I (50.0%) and PA II (18.2%) showed a lower proportion achieving visual acuity more than 20/260 than nonvascularized PA I (71.4%, 10/14).

--There was no significant difference in the prevalence of graft survival and vision outcome between infants younger than 6 months and older than 6 months.

Finally, the prevalence of graft survival and visual acuity were primarily linked to the indication in infants with PA who underwent PK. Corneal vascularization and an irregular lens were the major risk factors.

Source: https://journals.lww.com/corneajrnl/Fulltext/2021/06000/Penetrating_Keratoplasty_in_Infants_With_Peters.9.aspx
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