Study: Reproducibility of RNFL and Macular Ganglion Cell Lay
In myopic eyes, reproducibility of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell–inner plexiform layer thickness measurement by optical coherence tomography showed excellent reproducibility except for the temporal quadrant RNFL thickness measurement.

A Study was conducted to evaluate the long-term reproducibility of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell–inner plexiform layer (GCIPL) thickness measurements using optical coherence tomography (OCT) in myopic eyes.

65 eyes with moderate-to-high myopia (spherical equivalent less than -3.0 diopter [D], myopia group) and 53 eyes with low-to-no myopia without ocular disorders, such as glaucoma or retinal diseases, were included. Three serial OCT scans recorded at 1-year intervals were analyzed. Reproducibility was evaluated using within-subject standard deviation (Sw), coefficient of variation (CVw), and intraclass correlation coefficient (ICC).

Results:
--Mean±standard deviation refractive error was 0.30±0.80 and 6.26±2.45 D for control and myopia groups, respectively.

--The myopia group had thinner superior, inferior, and nasal quadrant RNFL, thicker temporal quadrant RNFL, and thinner GCIPL than the control group, except for the minimum and superotemporal GCIPL thicknesses.

--The myopia group had lower reproducibility in temporal quadrant RNFL thickness than the control group, whereas in other sectors of RNFL and all GCIPL parameters, comparable reproducibility was observed between the two groups.

RNFL and GCIPL thickness measures in moderate-to-high myopia had comparable long-term repeatability to that in low-to-no myopia, with the exception of RNFL thickness in the temporal quadrant. Changes in the RNFL and GCIPL should be considered.

Source: https://journals.lww.com/glaucomajournal/Abstract/9000/Reproducibility_of_Retinal_Nerve_Fiber_Layer_and.97535.aspx
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