Study: Tibiofemoral Articular Cartilage Composition Differs
Biochemical joint changes contribute to posttraumatic osteoarthritis (PTOA) development following anterior cruciate ligament reconstruction (ACLR). A study was conducted to compare tibiofemoral cartilage composition between ACLR patients with different serum biochemical profiles.

Serum was collected from 24 patients preoperatively and 6-months post-ACLR. Magnetic Resonance Imaging (MRI) was collected for medial and lateral tibiofemoral articular cartilage at 12-months post-ACLR. A k-means cluster analysis was used to identify profiles based on biomarker changes over time and relaxation times were compared between cluster groups controlling for sex, age, BMI, concomitant injury and Marx Score.

--1 cluster exhibited increases in MCP-1 and COMP while the other demonstrated decreases in MCP-1 and COMP preoperatively to 6-months post-ACLR.

--The cluster group with increases in MCP-1 and COMP demonstrated greater lateral tibial and femoral T1? relaxation times.

Conclusively, MRI changes consistent with lower lateral tibiofemoral cartilage proteoglycan density 12-months after ACLR are related with profiles of higher serum levels of inflammation and matrix degradation indicators preoperatively to 6-months post-ACLR.