Study: Virological Characteristics of Hospitalized Children
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The primary goal of this study is to see if there's a connection between SARS-CoV-2 viral load (VL) and age, disease severity, and underlying comorbidities in infected children. This research involved Children under the age of 21 who were screened for SARS-CoV-2 at the time of hospitalization and tested positive by polymerase chain reaction. VL was measured at various locations and compared between classes.

--Of the 102 children included in this study, 44% of the cohort had asymptomatic infection, and children with more than 1 comorbidity were the most at risk for severe disease.

--VL in children with symptomatic infection was significantly higher than in children with asymptomatic infection (3.0 × 105 vs 7.2 × 103 copies per mL).

--VL in the respiratory tract was significantly higher in children less than 1 year, compared with older children (3.3 × 107 vs 1.3 × 104 copies per mL respectively), despite most infants presenting with milder illness.

--Besides the respiratory tract, SARS-CoV-2 RNA was also detectable in samples from the gastrointestinal tract (saliva and rectum) and blood.

--In 13 children for whom data on duration of polymerase chain reaction positivity was available, 12 of 13 tested positive 2 weeks after initial diagnosis, and 6 of 13 continued to test positive 4 weeks after initial diagnosis.

Finally, Children with more than one comorbid illness who were diagnosed with SARS-CoV-2 had serious disease. In children with symptomatic disease and children under the age of one year, SARS-CoV-2 viral load in the respiratory tract is significantly higher.