Study confirms, the corneoscleral shape in Marfan syndrome i
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A Study was conducted to investigate the corneoscleral shape in Marfan syndrome (MFS) patients.

30 eyes of 15 participants with molecularly proven MFS were included in this prospective, cross-sectional study. Optical biometry, Scheimpflug imaging, and corneoscleral topography were performed in all patients.

Topographic data were compared to data from controls (25 emmetropes and 17 myopes). The raw 3-D anterior height data from MFS eyes and control eyes were exported for further analysis. Custom-made software was used to demarcate the limbal radius and to calculate the sagittal height in different concentric annuli centred at the corneal apex, placed in a pupil plane, for the central cornea (0–4 mm radius), peripheral cornea (4–6 mm radius) and sclera (6–8 mm radius) and the corneoscleral asymmetry.

Results:
--Marfan syndrome (MFS) eyes had significantly lower values of mean sagittal height compared to non-MFS eyes in all three annuli (central cornea, corneal periphery and sclera (independent t-test).

--The sclera was significantly more asymmetric in MFS eyes compared to myopes (independent t-test), but similar to emmetropes (independent t-test).

--In MFS eyes, scleral asymmetry was not found to be correlated with axial length.

In conclusion, patients with Marfan Syndrome have a peripheral cornea and sclera with a markedly different shape from healthy controls.

Source: https://onlinelibrary.wiley.com/doi/10.1111/aos.14636?af=R
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