Study finds, Activity of Deposited Lysozyme on Contemporary
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The amount of protein deposition on soft contact lenses and the degree to which the proteins are denatured can affect how long contact lenses can be worn comfortably. The aim of this study was to see how two lens care systems affected total protein, as well as the amount and behavior of lysozyme deposited on worn senofilcon A silicone hydrogel contact lenses.

In a 4-week prospective, randomized, bilateral eye, daily-wear, crossover, double-masked sample, 30 symptomatic soft contact lens wearers were enrolled. Participants were given senofilcon A lenses every two weeks and were given either a polyquaternium-1 and myristamidopropyl dimethylamine-based system or a peroxide-based system. Proteins were extracted from the lenses after each wear cycle and analyzed for total protein, total lysozyme quantity, and operation.

Results:
--The use of either the peroxide-based system or the polyquaternium-1 and myristamidopropyl dimethylamine-containing system resulted in no difference to the amount of total protein deposited on the lenses {6.7 ± 2.8 micrograms/lens versus 7.3 ± 2.8 micrograms/lens, respectively} or to the amount of denatured lysozyme deposits {0.8 ± 0.7 versus 0.9 ± 0.7 micrograms/lens}, respectively.

--The total amount of lysozyme deposited on the lenses was significantly lower when using the peroxide-based system {1.3 ± 0.9 micrograms/lens} compared to the polyquaternium-1 and myristamidopropyl dimethylamine-containing system {1.7 ± 1.0 micrograms/lens}.

Conclusively, the inactivation of lysozyme deposited on senofilcon A lenses when disinfected with the peroxide-based or the polyquaternium-1 and myristamidopropyl dimethylamine-containing systems were neither statistically nor clinically significant and the overall amounts of denatured lysozyme recovered from the lenses were low (less than 1 microgram/lens).

Source: https://www.dovepress.com/activity-of-deposited-lysozyme-on-contemporary-soft-contact-lenses-exp-peer-reviewed-fulltext-article-OPTH
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