Study finds, Alternative Etiologies of Liver Disease in Chil
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
A Study was conducted to determine the prevalence of alternative causes of liver disease in a cohort of youth with overweight and obesity undergoing evaluation for suspected nonalcoholic fatty liver disease (NAFLD).

Multicenter, retrospective cohort study of patients aged less than 18 years with overweight and obesity and evidence of elevated serum aminotransferases and/or hepatic steatosis on imaging, referred for suspected NAFLD were included. Testing was performed to exclude the following: autoimmune hepatitis (AIH), Wilson disease, viral hepatitis (B and C), thyroid dysfunction, celiac disease, alpha-1 antitrypsin deficiency, and hemochromatosis.

Results:
--A total of 900 children with overweight and obesity (63% boys, 26% Hispanic ethnicity) were referred, with a median age of 13 years (range: 2–18).

--Most had severe obesity (n = 666; 76%) with a median BMI z score of 2.45 (interquartile range [IQR]: 2.2–2.7).

--Median alanine aminotransferase level at presentation was 64 U/L (IQR: 42–95).

--A clinically indicated liver biopsy was performed in 358 children (40%) at a median of 6 months (IQR: 1–14) post initial visit; of those, 46% had confirmed nonalcoholic steatohepatitis.

--Positive autoantibodies were observed in 13% of the cohort, but none met criteria for AIH.

--Only 19 (2%) were found to have other causes of liver disease, with no cases of viral hepatitis or Wilson disease detected.

In a broad multicenter cohort, the vast majority of children with overweight and obesity who had NAFLD, whether suspected or confirmed, tested negative for other liver diseases.

Source: https://pediatrics.aappublications.org/content/early/2021/03/26/peds.2020-009829?rss=1
Like
Comment
Share