Study finds Association between Bone Mineral Density and exp
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Juvenile dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy in children and adolescents. Both the disease and its treatment with glucocorticoids may negatively impact bone formation. In this study, BMD in patients (children/adolescence and adults) is compared in long-standing JDM with matched controls; and exploration is done on how general/disease characteristics and bone turnover markers are associated with BMD.

59 JDM patients were compared to 59 age/sex-matched controls 16.8 years after the onset of the disease. Both participants had their BMD measured using dual-energy X-ray absorptiometry (DXA), but only those over the age of 20 had their ultra-distal radius, forearm, and total hip measured using DXA. The relationship between bone turnover markers and outcomes was investigated.

Results:
--Reduced BMD Z-scores were found in 19 and 29% of patients and 7 and 9% of controls in whole body and spine, respectively.

--BMD and BMD Z-scores for whole body and spine were lower in all patients and for less than 20y compared with their respective controls.

--In participants more than 20y, only BMD and BMD Z-score of forearm were lower in the patients versus controls.

--In patients, BMD Z-scores for whole body and/or spine were found to correlate negatively with prednisolone use at follow-up (yes/no) (age less than 20y), inflammatory markers and levels of interferon gamma-induced protein 10 (IP-10).

--In all patients, prednisolone use at follow-up (yes/no) and age more than 20y were independent correlates of lower BMD Z-scores for whole body and spine, respectively.

In conclusion, Children with long-term JDM have more BMD damage in the spine and across the body than adults. Both prednisolone and inflammatory markers were found to have associations with BMD, and a novel association with the biomarker of JDM development, IP-10, was discovered.

Source: https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-021-00543-z
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