Study finds, Association between Obstructive sleep apnea and
A Study was conducted to examine the association between apnea–hypopnea index (AHI, a measure for OSA severity) and metabolic morbidity among morbidly obese adolescents.

Researchers performed a population-based retrospective cohort study by reviewing sleep study, metabolic indices, and comorbidity-related data of a cohort (n=106) of adolescents referred to a bariatric surgery clinic. Subjects with moderate/severe OSA versus no/mild OSA and three groups of subjects with increasing body mass index (BMI) concerning sleep-study and metabolic indices were compared using univariate analyses.

--A total of 71 patients met the inclusion criteria. Subjects with moderate/severe OSA (n=32) had higher BMI, cholesterol, cholesterol/high-density lipoprotein (HDL) ratio, hemoglobin A1c, and serum ferritin levels.

--AHI significantly increased across BMI strata. Multivariate linear regression indicated that moderate/severe OSA was associated with higher levels of ferritin, unstandardized beta=49.1 (nIU/ml).

In short, the risk for metabolic problems in morbidly obese adolescents having moderate/strong OSA versus no/mild OSA is increased. In addition to weight loss, therapy of OSA should therefore be considered in teenagers with morbid obesity.