Study finds, Association between Retinal Morphology and Visu
A Study was conducted to evaluate the prevalence of retinal thinning and the correlation with papilledema and visual acuity (VA) in a large craniosynostosis population.

All syndromic and complex craniosynostosis patients were included. Retinal layers were segmented using optical coherence tomography (OCT). Patients were seen by an ophthalmologist for VA assessment and fundoscopy.

Multivariate regression models were developed to evaluate correlations between retinal thickness, papilledema and VA.

--127 patients were included. Retinal thinning was most prevalent in the peripapillary retinal nerve fiber layer (RNFL; up to 38%).

--A longer duration of papilledema in early childhood correlated to an increased peripapillary RNFL and TRT optic nerve head (ONH) later in life, however its’ thickness was not correlated to VA.

--Macular retinal thinning was associated with a worse VA, however it was not correlated to duration of papilledema.

Conclusively, the frequency of retinal ONH thinning is minimal following a prophylactic treatment plan for syndromic and complicated craniosynostosis. Although there is a high incidence of peripapillary RNFL thinning, its thickness is unrelated to VA. Macular thinning, on the other hand, is linked to lower VA scores and should be assessed throughout follow-up.