Study finds, Association between Structural and functional c
The nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) scans measured within 5° of the macula can be used to detect glaucomatous change. The photopic negative response (PhNR) of mfERG elicited by a circular stimulus centered on the fovea was significantly reduced in eyes with glaucoma.

For morphological assessments, ganglion cell complex (GCC) in 6 regions and the average were measured by optical coherence tomography (OCT). For functional assessment, Humphrey visual fields (VF) with mean sensitivities (MT) and mfERG scans with parameters of N/T and the multifocal photopic negative response to B-wave ratio (mfPhNR/B) were measured. 69 eyes of 44 glaucoma patients were included and correlations between mfERG parameters and OCT or VF parameters were evaluated.

Results:
--The mean deviation for all eyes obtained with the VF 30–2 and VF 10–2 was 7.00 and 6.31dB, respectively.

--Significant correlations between GCC thickness or VF parameter and the N/T were found, especially in the inferior and inforotemporal retinal areas corresponding to superior and superonasal VF sectors.

--However, similar associations were not obtained between mfPhNR/B and OCT or VF parameters. The mfPhNR/B only in the inferotemporal sector was significantly correlated with the average thickness of GCC.

The N/T was correlated with GCC and VF in more numbers of measurement areas than the mfPhNR/B in the current study.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-02061-8
Like
Comment
Share