Study finds, Association between stellate nonhereditary idio
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Stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) is a disorder characterized by splitting of the retina at the macula, without a known underlying mechanical or inherited cause. This study investigates demographic, anatomical and functional characteristics of subjects with SNIFR, to explore potential underlying mechanisms.

In this single-site, retrospective and cross-sectional, observational study, data were collected from 28 eyes from 24 subjects with SNIFR. Descriptive statistics were reported, based on the observed anatomico-functional features.

--Visual acuity remained stable (median 20/20) in all subjects over a median follow-up of 17 months. All cases demonstrated foveomacular retinoschisis within Henle’s fiber layer, at the junction of the outer plexiform and outer nuclear layers.

--This schisis cavity extended beyond the limits of the macular OCT temporally in all eyes.

--In the majority of affected eyes, there were documented features of peripheral retinoschisis and broad attachment of the posterior hyaloid at the macula.

--Functional testing in a cross-sectional subset demonstrated normal retinal sensitivity centrally but an absolute scotoma peripherally.

Finally, peripheral retinoschisis and anomalous or incomplete posterior hyaloid detachment tend to be associated with Stellate nonhereditary idiopathic foveomacular retinoschisis. About the fact that it manifests over time, it has little effect on central vision, but it can cause severe peripheral vision loss.