Study finds, Association between transcutaneous bilirubin an
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Transcutaneous bilirubin is used as a screening tool in preterm newborns before starting phototherapy. The researchers wanted to see whether there was a connection between transcutaneous bilirubin and serum bilirubin in Indian preterm newborns at different sites before, during, and after phototherapy. They found a strong link but weak agreement.
The study participants were 90 preterm newborns admitted for phototherapy within the first 7 days of life.

Within 30 minutes of each other, Draeger JM-105 was used to measure transcutaneous bilirubin at the covered areas of the sternum and forehead, and the Diazo method was used to measure serum bilirubin. Until beginning phototherapy, bilirubin levels were measured, and then every 12 hours for the next 24 hours.

Results:
--Median gestational age and mean birth weight of the enrolled infants were 33.5 weeks and 1920 g, respectively.

--Transcutaneous bilirubin from sternum demonstrated good correlation with serum bilirubin before (r = 0.856), during (r = 0.723 at 24 h), and after phototherapy (r = 0.801 at 24 h postphototherapy). Measurements from the forehead showed better correlation with serum bilirubin compared to the sternum (r = 0.865 before, 0.732 during, 0.814 after phototherapy).

--At both sites, correlation worsened with phototherapy but improved gradually in the postphototherapy period.

--Bland–Altman analysis revealed wide upper limit of agreement between transcutaneous bilirubin and serum bilirubin at both sites and all points of time, suggesting a transcutaneous device significantly overestimated serum bilirubin.

In conclusion, despite the timing and location of measurement, there was a strong association but weak agreement between transcutaneous bilirubin and serum bilirubin in Indian preterm newborns.

Source: https://www.jcnonweb.com/article.asp?issn=2249-4847;year=2021;volume=10;issue=2;spage=59;epage=67;aulast=Sardar
Like
Comment
Share