Study finds, Association between tuberculosis and Behçet dis
This study evaluates the associations between tuberculosis (TB) infection and risk of Behçet disease.

This study is a mendelian randomization and observational analysis of genetic data from 999 Chinese and 611 Japanese patients with uveitis associated with Behçet disease, and 5,154 control patients. Researchers tested for 5 single nucleotide variants (SNPs) that were previously linked to TB infection in genome-wide association studies of Chinese patients.

Researchers also tested for TB using T-SPOT.TB immunoassays. The primary outcome was the odds ratio for Behçet disease, estimated by an inverse variance weighted mean of associations with genetically determined TB susceptibility. The T-SPOT.TB immunoassay positivity rate was examined in patients with Behçet disease and control participants.

--The analysis revealed that TB susceptibility was associated with an increased risk for Behçet disease.

--The odds ratio for Behçet disease per 2-fold increase in TB incidence was 1.26 in the Chinese cohort and 1.16 in the Japanese cohort.

--In addition, a positive T-SPOT.TB immunoassay was an independent risk factor for Behçet disease (OR 2.26).

A 2-sample mendelian randomization was performed, meaning that there may still be confounding factors in the analysis. The data on T-SPOT positivity, however, does provide some additional indirect support for this association.

In individuals with a diagnosis of Behçet's disease, active or latent TB infection should be investigated particularly if an ophthalmologist assists in guiding immunosuppression treatments. Patients who are treated with Behçet disease should be mindful of the potential reactivation or development of TB.