Study finds, Association of Limbal Stem Cell Deficiency with
A Study was conducted to describe the demographic features and clinical characteristics of patients with herpes keratitis (HK) and limbal stem cell deficiency (LSCD) and identify possible factors associated with development of LSCD after HK.

In this retrospective case-series study, records of patients with a clinical diagnosis of HK seen over a 5-year period were reviewed for evidence of LSCD. Patient demographics, medical history, treatment, and best-corrected visual acuities (BCVAs) were recorded.

--Researchers identified 626 patients with HK. 57 had been diagnosed with LSCD, 13% of patients with herpes zoster keratitis and 7% of patients with herpes simplex keratitis had LSCD.

--Keratitis caused by herpes zoster virus [odds ratios (OR), 1.77], stromal involvement (OR, 2.28), and the use of topical antihypertensives (OR, 2.28) were found to be associated with a higher likelihood of developing LSCD.

--The final logarithm of the minimum angle of resolution BCVA was significantly lower in patients with LSCD compared with those without LSCD with a mean BCVA of 1.34 ± 1.52 LogMar as compared to 0.18 ± 0.54 LogMar in those patients without LSCD.

In conclusion, it appears that HK may be a risk factor for LSCD development. To lessen the risk of persistent ocular surface morbidity, patients with HK should be followed for the development of LSCD.