Study finds, Changes in Ganglion cell complex thickness in p
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The aim of this study was to investigate the possible differences in optical coherence tomography parameters during euthymic, manic, and depressive episodes in patients diagnosed with bipolar disorder. Neuroimaging studies in patients with bipolar disorder have suggested that a neuropathological process may be effective in this disease. Neurodegenerative changes in the retina can be followed by optical coherence tomography, a non-invasive imaging method that allows in vivo visualization of the retinal layers.

The study involved 150 bipolar disorder patients who were divided into three classes (50 patients in euthymic states, 50 patients in manic states, and 50 patients in depressive states) and compared to 50 healthy controls. The thickness of ganglion cell complexes was determined using spectral-domain optical coherence tomography's automated macular segmentation software.

Results:
--Ganglion cell complex thicknesses were thicker in all quadrants in patient groups than the control group but the differences were significant in perifoveal superior and perifoveal inferior quadrants.

--There were no differences in ganglion cell complex thickness among the patient groups.

Finally, spectral-domain optical coherence tomography evaluation of ganglion cell complex thickness may provide a clue for monitoring neurodegenerative changes in patients with bipolar disorder.

Source: https://www.nature.com/articles/s41433-021-01580-4?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed:+eye/rss/current+(Eye+-+Issue)
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