Study finds, Changes in Medial Meniscal 3-D Position and Mor
A Study was conducted to assess whether quantitative changes in the meniscus predicts progression from early knee osteoarthritis (OA) to knee replacement (KR).

A nested case–control study was conducted among Osteoarthritis Initiative participants: all 35 case knees with baseline Kellgren/Lawrence (K/L) grade less than 2 that had KR between 36 and 60 months were matched 1:1 by age, sex, and baseline K/L grade to 35 control knees without subsequent KR.

Quantitative 3-dimensional medial meniscus position and morphologic measures were determined from MRI at the visit just before KR and 2 years before. Paired t-tests and case–control odds ratios (ORs, standardized per SD of change in controls) were used to compare changes between groups.

--Cases and controls were similar.

--Compared to control knees, KR case knees displayed longitudinal changes, specifically, a decrease in tibial plateau coverage, an increase in meniscal extrusion, and a decrease in meniscal width.

--The odds for KR increased with greater reduction in the percentage of tibial plateau coverage (OR 2.28), a greater increase in maximal extrusion (OR 1.40), and a greater reduction of mean meniscal width (OR 2.01).

--The odds for KR increased with medial compartment cartilage thickness loss (OR 2.86) for comparison.

Finally, meniscal position and the morphological quantitative measurements in the knees with quickly advancing knee OA are linked with later KR. These results demonstrate that structural meniscus changes are linked to a significant clinical and economic outcome of the knee OA.