Study finds Changes in Retinal Oxygen saturation and vessel
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A study was conducted to examine changes in retinal oximetry and retinal vasculature diameter in patients with chronic kidney disease (CKD), as well as associations between retinal vasculature and estimated glomerular filtration rate (eGFR), providing a theoretical basis for the early detection and diagnosis of CKD.

After receiving informed consent, 83 patients with CKD and 103 healthy people were included in the study. The arterial (SaO2) and venous (SvO2) oxygen saturations, as well as the arteriovenous difference in oxygen saturation (SavO2), were measured in all participants using noninvasive technology. The diameters of the corresponding retinal arterioles (DA) and venules (DV) were measured. The serum creatinine concentration was used to measure the eGFR of patients with CKD.

Results:
--In general, patients with CKD had higher mean SaO2 values than healthy individuals (100.15 ± 4.68% versus 97.14 ± 4.22%).

--The mean SaO2 in the superior temporal, superior nasal and inferior nasal quadrants significantly increased. There was no significant difference measured in the SvO2 when patients with CKD (63.66 ± 5.29%) and healthy individuals (62.70 ± 5.27%) were compared.

--The mean Sa?vO2 of the CKD group (36.49 ± 4.98%) was increased compared with normal subjects (34.44 ± 4.76%).

--The retinal arteriole diameter was narrower in patients with CKD than in normal individuals (117.53 ± 14.88 ?m versus 126.87 ± 14.98 micrometre), and the arteriovenous ratio was smaller than in normal individuals (0.71 ± 0.09 versus 0.77 ± 0.09).

--Pearson’s two?tailed correlation showed a significant correlation between the SaO2 and eGFR (R = ?0.363), and narrower retinal arterial calibre was significantly associated with a lower eGFR (R = 0.415).

According to these findings, there were changes in retinal oxygen saturation and vascular diameter in CKD patients.

Source: https://onlinelibrary.wiley.com/doi/10.1111/aos.14398?af=R
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