Study finds, Clinical Characteristics and Neurodevelopmental
Neonatal stroke can potentially result in significant neurological sequelae in affected infants. Researchers aimed to describe the clinical characteristics, diagnostic evaluation, and neurodevelopmental outcomes of a cohort of infants with neonatal stroke.

A retrospective cohort study of infants with neonatal stroke were included. Maternal and infant characteristics were described. Placental pathology, echocardiogram results, and prothrombotic evaluations were reported. The neurodevelopmental outcomes using Bayley scale of infant development (BSID III), rates of epilepsy and cerebral palsy, and the need for rehabilitation therapies at two years were described.

--During the study period, 55 infants had neonatal stroke. Majority (93%) were term or late preterm infants.

--Maternal chorioamnionitis and perinatal HIE were diagnosed in about a third of the infants. Most (66%) of the infants presented with seizures.

--On brain MRI, the lesions were unilateral in 76% and arterial in origin in 86% of the infants.

--Meconium exposure, intrauterine inflammation/infection and fetal vascular malperfusion were seen on placental histopathology.

--At 2 year BSID III assessment, median composite cognitive, language, and motor scores were 100, 97, and 100, respectively.

--Among this cohort, epilepsy, cerebral palsy and the need for rehabilitation therapies were reported at two years.

Finally, seizures were prevalent in term or late preterm infants who had a neonatal stroke. In most newborns, it was unilateral and arterial in origin. At birth, the most typically linked disorders were maternal chorioamnionitis and perinatal HIE. At the age of two, almost one-fifth of the infants had mild or severe developmental deficits. At two years old, a considerable number of newborns had epilepsy, cerebral palsy, and required rehabilitation therapy.