Study finds, Clinical, Morphological, and Optical Correlates
The purpose of this article was to study the clinical, optical, and morphological correlates of visual function in patients with Fuchs endothelial corneal dystrophy (FECD).

The case records were analyzed for patients diagnosed with FECD. The best-corrected visual acuity (BCVA) was recorded as decimal visual acuity and converted to the logarithm of the minimum angle of resolution units. Contrast sensitivity was measured with the Pelli–Robson contrast sensitivity test. Corneal epithelial thickness was measured by spectral-domain optical coherence tomography.

--A total of 107 eyes of 61 patients with FECD were retrospectively investigated.

--The Spearman rank correlation coefficient showed moderate correlation between BCVA and contrast sensitivity with some patients maintaining relatively good BCVA but having reduced contrast sensitivity.

--Logistic regression analysis demonstrated that age, central corneal thickness, depression of the posterior cornea, and epithelial thickening were negatively associated with contrast sensitivity but not with BCVA.

Contrast sensitivity, is a valuable diagnostic for detecting visual dysfunction and should be included in the evaluation routine for patients with FECD. Corneal changes such as central corneal thickness, posterior corneal depression, and epithelial thickening may be objective parameters that might aid the doctor in rating the severity of the disease and following its course.