Study finds, Clinical features of advanced glaucoma with opt
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A Study was conducted to investigate the clinical characteristics of optic nerve head (ONH) prelaminar schisis in eyes with advanced glaucoma.

116 eyes with advanced glaucoma were included. ONH prelaminar schisis was identified using the spectral-domain optical coherence tomography independently by 2 evaluators and only eyes that reached to consensus for the presence of ONH prelaminar schisis were included. Bruch's membrane opening-minimum rim width (BMO-MRW), thickness and depth of lamina cribrosa (LC), peripapillary retinal nerve fiber layer (RNFL) thickness, macular thickness (total, RNFL, ganglion cell layer, inner plexiform layer), and peripapillary and subfoveal choroidal thickness were additionally obtained. Clinical characteristics were compared between the two groups based on the presence of ONH prelaminar schisis.

--ONH prelaminar schisis was identified in 48 of 116 eyes.

--Multivariate logistic regression analysis revealed that short axial length, thin and deep LC, and thick macula were associated with the presence of ONH prelaminar schisis.

--When the structure-function relationships were determined, macular structural parameters tended to have a better relationship with functional parameters than the BMO-MRW and peripapillary RNFL thickness parameters in eyes with ONH prelaminar schisis.

The thin and deep LC, short axial length and thick macula were finally connected with the prelaminary schism of the ONH. In patients with these characteristics, macular measurements better predict the functional condition of the eye rather than peripapillary or ONH measures. These findings may have major clinical effects with and without ONH prelaminary schisis for the management of advanced glaucoma eyes.