Study finds, Clinical risk factors associated with radiograp
The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis.

A longitudinal study was conducted within a randomised controlled trial, the “Long-term Evaluation of Glucosamine Sulfate” (LEGS study). Community-dwelling people with chronic knee pain (more than 4/10) and medial tibiofemoral narrowing (but retaining more than 2mm medial joint space width) on radiographs were recruited.

From 605 participants, follow-up data were available for 498 (82%). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden’s nodes, history of knee surgery/trauma, and manual occupation.

Radiographic osteoarthritis progression was defined as joint space narrowing more than 0.5mm over 1 to 2 years (latest follow-up used where available).

--Radiographic osteoarthritis progression occurred in 58 participants (12%).
--Clinical factors independently associated with radiographic progression were the use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05, and not meeting physical activity guidelines, OR 2.07.

In conclusion, those who use NSAIDs and/or do not follow the Guidelines of Physical Activity are more likely to get radiation arthritis in those with mild radiographic knee arthritis.