Study finds, Clinicopathologic Characteristics and Prognosti
A Study was conducted to examine the prognostic factors for survival in patients with melanoma of the eyelid.

Patients with primary melanoma of the eyelid were diagnosed.
Survival rates estimated by Kaplan-Meier analysis and mortality hazard ratios(HRs) for overall survival(OS) and disease-specific survival(DSS).

--The cohort consisted of 2257 patients with cutaneous melanoma in the eyelid, representing 1380 cases of melanoma in situ and 877 cases of invasive melanoma.

--For melanoma in situ and invasive melanoma respectively, at 5-years, the OS rates were 88.6% and 77.1%, while DSS rates were 99.4% and 91.0%.

--Cox regression analysis for eyelid melanoma indicated that for invasive melanoma, age at diagnosis more than 75 years, T4 staging (HR 8.45), lymph node involvement (HR 3.61), and nodular melanoma (HR 3.31) histological subtype were associated with decreased rates of survival.

--Sex and tumor ulceration did not impact survival.

To summarize, this study is the largest analysis of DSS for cutaneous melanoma of the eyelid to date. Age 75 years or older at diagnosis, T4 staging, lymph node involvement, and the nodular melanoma histological subtype are the most important predictors of invasive melanoma survival.