Study finds, Corneal Allograft Rejection is associated With
The purpose of this article is to report 3 cases of corneal allograft rejection that occurred in temporal proximity to administration of the zoster subunit vaccine (RZV).

3 cases of corneal transplant rejection that developed after RZV administration were identified. Clinical history, including existence of other risk factors, timing of rejection, corticosteroid therapy at the time of onset of rejection, and course were reviewed.

--The onset of symptoms occurred 5 weeks after the first RZV dose in 1 patient and 1 and 6 weeks after the second dose in the other 2 patients.

--Coexisting risk factors included history of endothelial keratoplasty in the fellow eye in 1 patient and previous failure of a penetrating keratoplasty because of rejection in a second patient.

--The third patient had a history of 1 episode of rejection in a previous graft that resolved and then experienced graft failure over several years.

--In 2 patients, rejection developed despite relatively high levels of topical steroid therapy: prednisolone acetate 1%, 4 × per day in 1 patient and difluprednate 0.05%, 3 × per day in a second patient.

Conclusively, the probability of allograft rejection in immunocompetent patients with previous endothelium or penetrating corneal transplants is increasing in RZV, which elicit more powerful immune reaction than the zoster live-atmenuated vaccine ZVL. It may be permissible, until around 3 months from the second dose of ZVL, to increase the topical corticosteroid regimen before the first dose.