Study finds, Corneal Stromal Regeneration Therapy for Advanc
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A Study was conducted to report the 3-year clinical outcomes of corneal stromal cell therapy consisting of the intrastromal implantation with autologous adipose-derived adult stem cells (ADASCs), and decellularized or ADASC-recellularized human donor corneal laminas in advanced keratoconus.

3 experimental groups of 14 patients were formed. Patients in Group 1 (G-1) had only ADASCs (3 x 106 cells/1 mL) implanted (n = 5). Patients in Group 2 (G-2) (n = 5) received a 120-m decellularized corneal stroma lamina. Patients in Group 3 (G-3) got a 120-m lamina that had been recellularized with ADASCs (1 x 1000000 cells/1 mL) (n = 4). ADASCs were acquired by liposuction surgery. Under topical anesthetic, the implant was placed into a femtosecond pocket.

Results:
--At 3 years, a significant improvement of 1 to 2 logMAR lines in uncorrected distance visual acuity was observed in all groups.

--A statistically significant decrease in corrected distance visual acuity was obtained in G-2 and G-3 when compared with that of G-1.

--Rigid contact lens distance visual acuity showed a statistically significant worsening in G-2 compared with that of G-1.

--A statistically significant increase in central corneal thickness was observed in G-2 and G-3; in the Scheimpflug corneal topography, the thinnest point was observed in G-2 and G-3 when compared with that of G-1.

Finally, 3 years after ADASCs and decellularized or ADASC-recellularized human corneal stroma laminas were implanted intrastromally, there were no problems. In advanced keratoconus, the procedure showed a moderate improvement in (uncorrected distance visual acuity) and (corrected distance visual acuity).

Source: https://journals.lww.com/corneajrnl/Abstract/2021/06000/Corneal_Stromal_Regeneration_Therapy_for_Advanced.12.aspx
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