Study finds, Corneal endothelial cells changes in different
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A Study was conducted to assess the corneal endothelial cells morphology and count in keratoconus patients and their correlation with different stages of keratoconus.

Prospective non randomized multi-centric clinical study included 150 eyes of 150 keratoconus patients. Pentacam (Wavelight Oculyzer II) and specular microscopy (Tomey EM-3000) were done to all eyes. Keratoconic eyes were classified according to Amsler classification into stage 1, 2 and 3. Stage 1 included 99 eyes, stage 2 included 32 eyes & stage 3 included 19 eyes.

Results:
--The mean age of keratoconus patients was 24.07±6.154 years.

--45 cases were males (30%) and 105 cases were females (70%).

--There was statistically significant difference in endothelial cell density and coefficient of variation between different stages of keratoconus eyes.

--Regarding cell surface area, there was statistically significant difference in cell surface area between different stages of keratoconus eyes.

--In addition, for cell morphology, there was statistically significant difference between different stages of keratoconus eyes.

In conclusion, qualitative and quantitative structural changes in endothelial cells of keratoconus eyes were observed using specular microscopy. Keratoconus does not have a major impact on the corneal endothelim in stages 1 and 2. In stage 3, the endothelium experiences major changes in terms of polymegathism and pleomorphism.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-01913-7
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