Study finds, Differences Between Pediatric Acute Myocarditis
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Acute myocarditis (AM) is defined as inflammation of the myocardium. The aim of the study was to do a comparative analysis of the differences between AM related and unrelated to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

The retrospective study included 24 children treated with AM.

Results:
--7 of 24 had AM related to SARS-CoV-2 and they were older than 7. They were more likely to have abdominal pain, headache, cutaneous rash, and conjunctivitis, while fulminant myocarditis was commonly registered in AM unrelated to SARS-CoV-2.

--A multisystem inflammatory syndrome in children associated with COVID-19 was diagnosed in 6 adolescents. Patients with AM related SARS-CoV-2 had lower serum cardiac troponin I (cTnI), and platelets, but had a higher C-reactive protein (CRP) value, and N-terminal-pro hormone BNP in comparison to patients with AM unrelated to SARS-CoV-2.

--The patients with AM related to SARS-CoV-2 had significant reduction of CRP. Inotropic drug support was used for shorter durations in patients with AM related to SARS-CoV-2, than in others.

--Children with AM related to SARS-CoV-2 had significant improvement of left ventricle systolic function on the third day in hospital.

--Patients with AM unrelated to SARS-CoV-2 AM had more frequent adverse outcomes (3 died and 4 had dilated cardiomyopathy).

In conclusion, patients with AM linked to SARS-CoV-2 had a higher CRP value, polymorphic clinical appearance, shorter durations of inotropic drug usage, and prompt recovery of left ventricle systolic function than patients with AM unrelated to SARS-CoV-2.

Source: https://journals.lww.com/pidj/Fulltext/2021/05000/Differences_Between_Pediatric_Acute_Myocarditis.1.aspx
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