Study finds, Distinct Lung Function and Bronchodilator Respo
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Recurrent or unresolved wheezing is a common complaint in certain young children populations, especially those born preterm. Using infant lung function testing, researchers aimed to distinguish the differences between term and preterm young children with recurrent wheezing.

Children under 2 years of corrected age were enrolled if they had 3 or more wheezing episodes during the enrollment period. For comparison, healthy term controls of similar age were also recruited. Tidal breathing, passive respiratory mechanics, and forced tidal and raised-volume expiration were all used to assess lung function. After an effective distribution of bronchodilator nebulization was achieved, raised-volume forced expiration was replicated for children with chronic wheezing.

--In total, 68 young children (40 with recurrent wheezing and 28 healthy controls) were recruited.

--Among children with recurrent wheezing, 23 preterm children (preterm group), and 17 term children (term group) were enrolled. Compared with healthy controls, both the term and preterm groups had lower lung function as measured by absolute values and z scores.

--The term group performed worse than the preterm group with regard to forced vital capacity, forced expiratory volume at 0.5 s (FEV0.5), and peak expiratory flow.

--Following bronchodilator nebulization, the term group had significantly higher increases in FEV0.5 and forced mid-expiratory flow than the preterm group.

Finally, children with chronic wheezing, especially term infants, had lower lung function than healthy controls. Furthermore, the term group showed greater bronchodilator responsiveness than the preterm group. The different bronchodilator responses could help direct the diagnosis and treatment of young children who have chronic wheezing.