Study finds, Effect of Medical Lowering of Intraocular Press
Reduction of intraocular pressure (IOP) by latanoprost in treatment-naive eyes is significantly correlated to an increase in vessel density (VD) at the optic nerve head (ONH).

A Study was conducted to evaluate the effect of topical latanoprost on ocular microvasculature using optical coherence tomography angiography (OCTA).

In this prospective case-control study, 26 eyes from 18 treatment-naive subjects in whom prostaglandin analogue (PGA) latanoprost 0.005% was initiated were included as cases. In 10 out of the 18 subjects, medication was initiated in only 1 eye; their contralateral untreated eyes were used as controls. OCTA was performed at baseline and more than 3 weeks after commencing treatment.

Main outcome measures were change in flow area and VD at the ONH, radial peripapillary capillaries (RPC), and macula. Comparison between the 2 visits was performed using a linear mixed model adjusted for intereye correlation and mean ocular perfusion pressure.

--IOP decreased by 26.1%±11.3% in the cases and 0.18%±12.2% in controls.

--Significant correlations between change in IOP and change in ONH VD, and between change in IOP and change in RPC VD were observed in the cases, whereas none were observed in the controls.

--When multiple testing was considered, no significant changes in flow area and VD were observed in cases and controls.

In the end, a PGA drop in IOP was strongly linked to the increase in ONH VD and RPC VD in treatment-free eyes. This may suggest a method by which the risk of glaucoma progression is modulated by IOP lowering, which improves ocular microperfusion.