Study finds, Effect of combined pulmonary fibrosis and emphy
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The aim of this research was to compare the clinical characteristics and prognosis of patients with connective tissue disease (CTD) with combined pulmonary fibrosis and emphysema (CPFE) to those of patients with CTD-interstitial lung disease (CTD-ILD) without emphysema based on a systematic review of the literature.

Studies meeting all the following criteria were included:
(1) Original research studies evaluating the effect of CPFE on CTD,
(2) Studies that compared patients with CTD-CPFE to those with CTD-ILD without emphysema, and
(3) Studies providing data on physical capacity, pulmonary function, or death in patients with CTD.

Clinical characteristics of patients with CTD-CPFE were compared with those of patients with CTD-ILD without emphysema, and the influence of CPFE on physical capacity, pulmonary function, and death was analyzed.

Results:
6 studies were included. 299 and 715 patients had CTD-CPFE and CTD-ILD without emphysema, respectively.

--Regarding the type of CTD, 711 patients had systemic sclerosis, 263 rheumatoid arthritis, and 67 other CTDs.

--Patients with CTD-CPFE had a higher frequency of pulmonary hypertension and pulmonary fibrosis than more?20% of the total lung volume, higher ratio of the forced vital capacity to the diffusion capacity of the lung for carbon monoxide (DLCO), lower arterial oxygen pressure at rest, and lower DLCO compared to those in patients with CTD-ILD without emphysema.

--In addition, more deaths occurred among those with CTD-CPFE (odds ratio, 2.95).

In conclusion, CTD-CPFE is linked to poor physical and pulmonary function, as well as an increased risk of death, when compared to CTD-ILD without emphysema. These results suggest that patients with CTD-CPFE should be more conscious of their condition and closely monitored.

Source: https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-021-02494-y
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