Study finds, Effects of Antihypertensive and Anticholinergic
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This study aimed to examine the association between commonly prescribed medications and outcomes following posterior lumbar spine surgery.

Postoperative complications and prolonged length of stay significantly increases costs following posterior lumbar spine surgery and worsens patient outcomes. To control costs and complications, providers should focus on modifiable risk factors, such as preoperative medications. Antihypertensive and anticholinergic drugs are among the most commonly prescribed medications but can carry significant risks in the perioperative period.

This study was a retrospective cohort analysis of patients undergoing posterior lumbar spine surgery. The variable selection followed by multivariable logistic and negative binomial regressions were performed. A secondary analysis was performed to evaluate confounding or effect modifying variables.

Results:
--This study included 1577 patients. Postoperative urinary retention risk was increased in patients taking loop diuretics.

--Acute kidney injury risk was increased for patients on nondihydropyridine calcium-channel blockers.

--Surgical site infection risk was increased for patients on aldosterone receptor blockers.

--Urinary tract infection risk was increased for patients on anticholinergics for urinary incontinence.

--Length of stay was decreased for patients on angiotensin II antagonists and angiotensin-converting enzyme inhibitors.

Finally, in peri-operative patients who are considered to be at greater risk for medication status, a care pathway should be devised to either amend medicines or strengthen post-operative surveillance.

Source: https://journals.lww.com/jspinaldisorders/Abstract/2021/06000/A_Retrospective_Cohort_Study_of_Effects_of.14.aspx
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