Study finds, Effects of Beta-Zone Peripapillary Atrophy and
The development of beta-zone peripapillary atrophy and focal lamina cribrosa defect was significantly associated with decreased peripapillary optical coherence tomography angiography vessel parameters in young myopic eyes.

A Study was conducted to investigate whether beta zone peripapillary atrophy (beta-PPA) and focal lamina cribrosa defect (FLD) affect peripapillary vessel density (VD) or perfusion density (PD) from optical coherence tomography angiography (OCTA) in young myopic eyes.

330 eyes of 165 healthy myopic individuals were participated in a cross-sectional investigation. For measuring peripapillary PD and VD, the eyes were subject to the OCTA. Eyed without beta-PPA or FLD, eyes with beta-PPA (group A), eyes with beta-PPA but without FLD (group B), and eyes with both beta-PPA and Fleda eyes were grouped according to their respective existence (group C). Three groups compared the PD and VD, with the PD determinants being investigated using the linear mixed effect regression model.

--Beta-PPA was found in 219 eyes and FLD was detected in 27 eyes. The average VD and PD were greatest in group A, followed by group B and group C.

--The linear mixed-effect model demonstrated that presence of FLD or beta-PPA, FLD count, and maximal beta-PPA width were significantly associated with average PD after controlling for multiple confounding factors.

Conclusively, development of beta-PPA and FLD, which is closely related with axial elongation in myopic eyes, was significantly associated with reduced OCTA vessel parameters in young myopic eyes. OCTA may help to detect vascular changes and assess glaucoma risk in these eyes.