Study finds, Effects of Herpes Simplex Keratitis scar locati
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A Study was conducted to evaluate the impact of herpes simplex virus (HSV)-induced scar location on bilateral corneal nerve alterations using laser in vivo confocal microscopy (IVCM).

Central and peripheral corneal subbasal nerve density (CSND) were assessed bilaterally in 39 patients with unilateral HSV-induced corneal scars (21 central scars (CS), 18 peripheral scars (PS)) using IVCM. Results were compared between patients and 24 age-matched controls. CSND was correlated to corneal sensation for all locations.

--Overall patients revealed significant decrease of CSND in the central and peripheral cornea, compared with controls.

--CS group showed a decrease in central and total peripheral nerves of the affected eyes, whereas PS group demonstrated a decrease in central and localised peripheral nerves only in the scar area.

--In contralateral eyes, CSND decreased in the central cornea of the CS group, and in the peripheral area, mirroring the scar area in the affected eyes of the PS group.

--Corneal sensation significantly decreased in the whole cornea of the affected, but not in contralateral eyes. A positive correlation between CSND and corneal sensation was found in all locations.

Finally, IVCM shows that patients with HSV scars have a reduction in bilateral CSND. In affected eyes, CSND and corneal sensation decrease in both the central and peripheral corneas, but only in the scar region in the PS group. Surprisingly, CSND was found to be reduced locally in the contralateral eyes, which matched and mirrored the scar position in the affected eyes.