Study finds, Epiretinal membrane appearance or progression a
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The aim of this study is to see whether anti-vascular endothelial growth factor (VEGF) plays a role in the emergence or progression of epiretinal membranes (ERMs) in age-related macular degeneration (ARMD) and to look into possible confounding factors.

The researchers looked at 76 eyes that had been treated for more than 36 months since the first anti-VEGF injection. Smoking, lens status, subretinal hemorrhage, posterior vitreous detachment (PVD) status, peripheral retinal degeneration, type of AMD, contralateral eye disorders, and the amount of injections were used as independent variables, with the presence or development of ERMs over 36 months as the dependent variables.

Results:
--The presence of vitreomacular adhesion (VMA) or development of PVD during the observation period was significantly associated (Odds ratio [OR]: 5.77) with the appearance or progression of ERMs.

--Moreover, peripheral retinal degeneration was significantly associated.

--Injection number of anti-VEGF was not significantly associated (OR: 1.02).

In conclusion, this study indicates that anti-VEGF injections alone are unlikely to trigger the development of ERMs, that VMA or developing PVD has a prior effect on the development of ERMs in ARMD, close to that of idiopathic ERMs, and that peripheral retinal degenerations and vitreomacular adhesion are both linked to ERMs development and ARMD pathogenesis.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-01944-0
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