Study finds, Expression of hedgehog signaling molecules in m
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Microcystic adnexal carcinoma (MAC) is a rare skin neoplasm that has not been characterized on a molecular basis. Researchers aimed to assess expression profiles of hedgehog (HH) signaling molecules in MAC and control tumours.

Immunohistochemistry was performed for Sonic HH (SHH), Indian HH (IHH), Patched 1 (PTCH1), and Smoothened (SMO) on patients’ MAC (n=26) tissue and control tumour tissue, including syringoma (SyG; n=11), trichoepithelioma (TE; n=11), and basal cell carcinoma (BCC; n=12).

Results:
--PTCH1 and SMO immunoreactivity was significantly higher in BCC than in SyG, TE, and MAC.

--The highest IHH expression was observed in BCC and TE when compared to SyG and MAC.

--Notably, the highest SHH protein expression was observed in SyG as compared to MAC, TE, and even BCC. In MAC patients, SMO immunoreactivity significantly (r = 0.51) correlated with PTCH1 expression.

--Further correlation studies did not show significant associations between the HH expression markers assessed.

In comparison to the morphologically related BCC and TE, these findings suggest that alterations in HH signaling are unlikely to play a major role in the pathogenesis of MAC.

Source: https://onlinelibrary.wiley.com/doi/10.1111/ced.14634?af=R
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