Study finds, Glaucoma conversion of the contralateral eye in
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A Study was conducted to investigate the clinical characteristics and risk factors for glaucoma conversion of the contralateral eye in unilateral normal-tension glaucoma (NTG) patients.

A retrospective observational cohort study was conducted on a total of 76 subjects who had been diagnosed with unilateral NTG at the baseline and followed up for more than 5 years. Glaucoma conversion in the contralateral eye was defined as increased thinning of neuro-retinal rim, development of retinal nerve fibre layer defect and/or development of glaucomatous visual field defect.

--During the mean follow-up period of 7.3±2.4 years, 21 of 76 subjects were confirmed to have developed glaucoma in the non-glaucomatous contralateral eye. The 5-year rate of glaucoma conversion in contralateral eyes was 19.7%.

--The maximum width of beta-zone parapapillary atrophy (MWbetaPPA)-disc diameter (DD) ratio at the baseline and the presence rate of disc haemorrhage during follow-up period were significantly greater in the contralateral eyes of the conversion group than in those of the non-conversion group.

--A multivariate Cox-proportional hazard model revealed intraocular pressure (IOP) over 17 mm Hg (HR 5.05), central corneal thickness (CCT) under 491 microm (HR 4.25) and MWbetaPPA-DD ratio over 0.32 (HR 6.25) in contralateral eye at the baseline as the independent risk factors for glaucoma conversion.

Conclusively, Among unilateral NTG patients, those with low CCT and high MWbetaPPA-DD ratio as well as high IOP in the contralateral eye are more likely to develop glaucoma in that eye during long-term follow-up.