Study finds, Health-related quality of life in Children diag
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Vernal keratoconjunctivitis (VKC) is a chronic, bilateral allergic disease that mostly affects children. Clinical assessments can not always reflect the disease's effect on a patient's health-related quality of life (HRQoL). The aim of the study was to assess HRQoL in children with VKC at the time of diagnosis and to look for associations between HRQoL and clinical and laboratory variables.

Study included 5 to12 years old patients with VKC. Data on clinical history, instrumental eye evaluations, blood exams and Visual analogue scale (VAS) for the subjective symptoms were collected. HRQoL was assessed through a disease-specific validated Quality of Life in Children with Vernal Keratoconjunctivitis (QUICK) Questionnaire.

--70 subjects were included in the analysis (Female/Male: 10/60; Tarsal/mixed VKC form: 36/34).

--Clinical severity of VKC according with Bonini scale was: 14 mild, 36 moderate and 20 severe.

--No significant difference was found concerning distribution of patient age, gender, history of allergic manifestations between tarsal and mixed VKC.

--A significant positive correlation was found between all QUICK scores and VAS scores, including different VAS subscale, while no significant correlation was found between QUICK scores and total signs scores, Schirmer test, and corneal thickness.

--The presence of active severe VKC was not associated with worse HRQoL.

In conclusion, this evidence indicates that VKC patients have poor HRQoL, especially in relation to the interpretation of symptoms, regardless of ophthalmological changes, and that the Fast questionnaire may be a useful tool for assessing HRQoL in children with VKC, potentially improving patient classification and management.