Study finds, High dose of Tramadol is Safe & Efficient for
A Study was conducted to examine the efficacy and safety of tramadol for knee or hip osteoarthritis (OA).

Randomized controlled trials (RCTs) comparing any of the following interventions: tramadol 100 mg/day, 200 mg/day and 300 mg/day, and placebo for knee or hip OA were searched. Pain and function were measured at or nearest to 12 weeks for efficacy. Gastrointestinal, cardiovascular and central nervous system adverse effects (AEs), and withdrawals were measured for safety. Bayesian network meta-analysis was conducted.

--6 RCTs (3,611 participants) were included.

--Tramadol 100 mg/day , 200 mg/day and 300 mg/day were statistically more effective than placebo in pain relief, but only tramadol 300 mg/day was better than placebo in functional improvement.

--Tramadol 100 mg/day, 200 mg/day and 300 mg/day involved a higher risk of gastrointestinal AEs. Similarly, tramadol 100-300 mg/day showed a higher risk of CNS AEs and withdrawals.

In conclusion, only tramadol 300mg/day showed a marginal improvement in pain and function compared to placebo, although with increased AEs. According to the research, tramadol may not be properly suggested for knee or hip OA, especially in patients who are at risk for gastrointestinal and CNS adverse effects.

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