Study finds, Inflammatory bowel disease in uveitis patients
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A Study was conducted to investigate the potential association between uveitis and an increased risk of developing inflammatory bowel disease (IBD).

Researchers conducted a retrospective cohort study to identify uveitis patients and age- and gender-matched controls. The cumulative incidence rates of subsequent IBD in the two groups were compared. The adjusted hazard ratio (HR) of IBD related to uveitis was generated by a multivariate cox regression model after adjustment for hypertension, diabetes, hyperlipidaemia, obesity and smoking. Furthermore, the HRs of the Crohn’s disease (CD) and ulcerative colitis (UC) IBD subtypes were calculated separately.

Results:
--A total of 198,923 subjects with uveitis and 397,846 controls were enrolled. The mean age of the cohort was 47.7±18.9 years.

--A significantly higher cumulative incidence of IBD was found in the uveitis group than in controls (4.13% vs. 1.48%).

--Under univariate cox regression analysis, uveitis patients had a significantly higher risk of IBD (HR=1.47).

--The association remained significant in the multivariate regression model, with an adjusted HR of 1.44.

--Moreover, in subgroup analysis, uveitis was significantly associated with an increased risk of Crohn’s disease, but not with ulcerative colitis.

In conclusion, Uveitis patients are far more likely to acquire IBD than people who do not have uveitis.

Source: https://www.nature.com/articles/s41433-021-01645-4?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed:+eye/rss/current+(Eye+-+Issue)
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