Study finds, Long-term outcomes of intravitreal anti-VEGF th
A Study was conducted to describe real-life data from wet age-related macular degeneration (AMD) patients treated with anti-vascular endothelial growth factors (VEGFs) and to compare our results with previous studies and clinical trials.

This retrospective monocentric cohort study analyzed 865 eyes of 780 wet-AMD patients treated with an anti-VEGF treat-and-extend regimen over a long-term follow-up period. Aflibercept and Ranibizumab were considered first-line agents whereas Bevacizumab was reserved for use on a compassionate basis in patients not meeting treatment criteria. All patients underwent a best corrected visual acuity (BCVA) assessment at each follow-up visit.

Results:
--Patients treated with Bevacizumab received fewer yearly injections than those treated with Ranibizumab.

--However, no significant difference in the number of injections per year was detected in other comparisons between groups.

--Whilst our data showed no significant difference in mean BCVA between the three groups, there was a gradual deterioration of visual function over time for the patient cohort as a whole.

Conclusively, No significant differences between the 3 anti-VEGF molecules were recorded in wet-AMD patients in real-life conditions. Despite the long-term therapy, researchers found a slight reduction in visual function especially after the third year of treatment.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-02055-6
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