Study finds, Longitudinal fFLT characteristics in geographic
Researchers investigated whether short fFLT could serve as a functional biomarker for disease progression in geographic atrophy (GA). Short foveal fluorescence lifetimes (fFLT) in geographic atrophy are typically found in eyes with foveal sparing (FS) but may also occur in eyes without FS.

33 eyes were followed over the course of 4-6 years. FS was assessed using fluorescence lifetime imaging ophthalmoscopy, OCT, FAF and macular pigment optical density.

--Eyes with FS exhibited shorter fFLT compared to eyes without FS.

--Short fFLT (less than 600ps) were measured in all eyes with FS and half of the eyes without FS. Eyes with FS showed a bigger increase in fFLT per year (+39/+30 ps (SSC/LSC) in FS vs. +29/+22 ps (SSC/LSC) in non FS).

--BCVA correlated significantly with fFLT. MPOD measurements correlated significantly with fFLT but not in all spectral channels.

Finally, shorter fFLT are associated with foveal sparing in GA, but they can also be seen in eyes that do not have FS. Shorter fFLT characteristics in eyes with loss of FS may signify an earlier stage of disease and may be more prone to loss of visual acuity, according to this longitudinal study.