Study finds, Low Rate of Spontaneous Closure in Premature In
A Study was conducted to assess the rate of spontaneous closure and the incidence of adverse events in infants discharged home with a patent ductus arteriosus.

In a prospective multicenter study, researchers enrolled 201 premature infants (gestational age 23-32 weeks at birth) discharged home with a persistently patent ductus arteriosus (PDA) and followed their PDA status at 6-month intervals through 18 months of age. The primary study outcome was the rate and timing of spontaneous ductal closure. Secondary outcomes included rate of assisted closure and the incidence of serious adverse events.

Results:
--Spontaneous ductal closure occurred in 95 infants at 12 months and 117 infants by 18 months.

--17 infants received assisted closure with surgical ligation or device assisted occlusion. 3 infants died.

--Although infants with spontaneous closure had a higher mean birth weight and gestational age compared with infants with a persistent PDA or assisted closure, other factors predictive of spontaneous closure were not identified.

Conclusively, Spontaneous closure of the PDA occurred in slightly less than half of premature infants discharged with a patent ductus by one year, lower than prior published reports. The high rate of assisted closure and/or adverse events in this population warrants close surveillance following discharge.

Source: https://www.jpeds.com/article/S0022-3476(21)00702-2/fulltext?rss=yes
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