Study finds, Morphological variants of Meibomian glands on I
This study describes the histopathological features of different morphological variants of human meibomian glands (MGs) seen on infrared imaging.

Tarsal plates dissected from seven cadaveric upper eyelids were imaged using infrared meibography, and then studied histopathologically using H&E, peroxisome proliferator-activated receptor gamma and Ki-67 antibody staining.

--Of the total 127 glands, the morphological variants observed on meibography based on size were: normal, short, severely short and dropout glands, and on shape were: hooked, tortuous, overlapping, thick and fluffy glands.

--Short, hooked, tortuous and overlapping glands had similar acinar and ductal histology as seen in normal glands whereas thick, and fluffy glands had increased acinar diameter.

--All glands except the severely short type demonstrated normal signs of holocrine secretory activity and normal nuclear and cytoplasmic PPAR expression.

--Severely short glands had nil while short glands had reduced Ki-67 proliferation index as compared with normal and other variants. Gland dropout areas showed no evidence of any glandular tissue on histology.

Finally, glands that were hooked, twisted, or overlapped had entirely normal glandular histology, but glands that were very short exhibited atrophic alterations with loss of meibocyte differentiation and cellular proliferation. There was a complete lack of glandular components in some locations.