Study finds, Outcomes of hybrid graft in patients with Modic
This retrospective study aimed to analyze the influence of Modic changes (MCs) on the clinical and radiographic outcomes of transforaminal lumbar interbody fusion with hybrid graft.

Clinical data of 89 patients with Modic changes who underwent single-segment transforaminal lumbar interbody fusion were analyzed. Patients were divided into three groups: the MCs-0 group (no endplate changes; used as the control group), the MCs-1 group, and the MCs-2 group. Clinical and radiological parameters were compared between the three groups.

Results:
--There were no significant between-group differences in age, sex, body mass index, smoking, diagnosis, surgical level, blood loss, operative time, or follow-up.

--Serum C-reactive protein level and erythrocyte sedimentation rate in the MCs-1 and MCs-2 groups were significantly higher than those in the MCs-0 group on the third and seventh days.

--Postoperative radiographic parameters were significantly higher than preoperative parameters in all 3 groups.

--Visual analog scale scores for low back pain in the MCs-0 and MCs-2 groups were significantly different from those in the MCs-1 group.

--However, there were no significant between-group differences with respect to Oswestry Disability Index scores or visual analog scale scores for leg pain.

Modic modifications had no effect on transforaminal lumbar interbody fusion with hybrid graft fusion rates or clinical outcomes in this investigation. MCs-1, on the other hand, increased the likelihood of cage subsidence and had better results on the visual analog scale for low back pain.

Source: https://josr-online.biomedcentral.com/articles/10.1186/s13018-021-02652-7
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